Barrett’s Esophagus

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Slides 151 - 156 of 298 Price: $0.00
  Slide 151

COX-2 Expression Increases During Neoplastic Progression  

  Slide 152

COX-2 Inhibition Reduces Esophageal Carcinoma in a Rat Model 

  Slide 153

To Become Cancers, Cells Must: 

  Slide 154

Normal Cells Undergo Senescence 

  Slide 155

Telomerase 

  Slide 156

Immortalization by Telomerase 


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Description:

This GTP unit consists of 298 images that review the epidemiology, pathogenesis, molecular biology and treatment of Barrett’s esophagus. This multimedia unit includes animations, endoscopic images, new techniques to detect metaplasia and dysplasia (e.g. chromoendoscopy and spectroscopy), histology, and videos demonstrating endoscopic ablation and endoscopic mucosal resection. The unit is divided into six sections:

1. Diagnosis and epidemiology of Barrett’s esophagus. This section highlights the prevalence of Barrett’s esophagus, its association with different factors, and the anatomical landmarks and histological findings required for diagnosis.

2. Pathogenesis of Barrett’s development. This section reviews normal esophageal physiology, and abnormalities in lower esophageal sphincter function, hiatal hernias and other abnormalities of the distal esophagus that are associated with the development of Barrett’s esophagus.


3. Progression of epithelial metaplasia to neoplasia. This section highlights the molecular mechanisms underlying progression of Barrett’s epithelium to dysplasia and cancer, with descriptive histology of the grades of dysplasia and cancer. Endoscopic photographs of lesions suspicious for cancer within Barrett’s mucosa and molecular markers that are associated with progression to cancer are included.

4. Screening and surveillance in Barrett’s esophagus. This section reviews the epidemiology of esophageal adenocarcinoma, clinical risk factors associated with progression of Barrett’s epithelium to dysplasia and cancer, and different modalities for screening and surveillance.

5. Treatment of Barrett’s esophagus and adenocarcinoma. This section reviews medical treatment (including chemoprevention), surgery and various endoscopic modalities.

6. Barrett`s Cases.

Senior Author:
Prateek Sharma, M.D.
Associate Professor of Medicine
University of Kansas School of Medicine
VA Medical Center
4801 E. Linwood Blvd.
Kansas City, MO 64128
e-mail: psharma@kumc.edu
tele: 816-861-4700, ext. 6737
fax: 816-922-4692

Co-Authors:
Gary Falk, M.D.
Cleveland Clinic GI Dept
9500 Euclid Avenue
Desk S-40
Cleveland, OH 44195-0001
e-mail: falkg@ccf.org
tele: 216-444-1762
fax: 216-444-9416

John Goldblum, M.D.
Dept of Anatomic Pathology L25
Cleveland Clinic Foundation
9500 Euclid Avenue
Cleveland, OH 44195
e-mail: goldblj@cesmtp.ccf.org
tele: 216-444-8238
fax: 216-445-6967

Richard Sampliner, M.D.
Southern Arizona VA Hlth Care Sys
3601 S 6th Avenue (111G-1)
Tucson, AZ 85723
e-mail: samplinr@u.arizona.edu
tele: 520-729-1450
fax: 520-629-4737

Rhonda Souza, M.D.
Dallas VA Medical Center
4500 South Lancaster Road
Gastroenterology 111B1
Dallas, TX 75216
e-mail: rsouza@airmail.net
tele: 214-374-0639
fax: 214-857-0328

Kenneth Wang, M.D.
Mayo Clinic
200 First Street SW
Gastroenterology E19B
Rochester, MN 55905
e-mail: wang.Kenneth@mayo.edu
tele: 507-284-2174
fax: 507-255-7612


Artists:
Stan Coffman
Medical Illustrator
Chapel Hill, NC

Jerry Schoendorf, MAMS
Chapel Hill, NC

Release Date:

May 15, 2004